MyBioSource.com's Anti-KAZALD1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-KAZALD1 Antibody, Rabbit Polyclonal was generated using KAZALD1 as the antigen and it reacts with Human.
Description
KAZALD1, also known as IGFBP-rP10, belongs to the IGFBP family. We found that KAZALD1 was hypomethylated in high-grade glioma (anaplastic gliomas and glioblastomas) compared to low-grade glioma (astrocytoma, oligodendrocytoma and oligoastrocytoma) using methylation microarrays (p<0.001). Decreased KAZALD1 expression in glioma inhibited cell proliferation and invasion both in vitro and in vivo. KAZALD1 promoter hypomethylation is an important prognostic biomarker in glioma. KAZALD1 promotes glioma malignant progression through invasion and proliferation